Current trends of neurootological pharmacotherapy
Abstract
Major neurootological complaints, which mostly need drug treatment, are: giddiness,
dizziness, hearing loss and tinnitus. The neurootological differential diagnosis is the basis
for planning the mostly supportive treatment of vertigo patients. In planning the therapy, we
are utilizing a computerbased expert system CLAMEDEX for establishing the
neurootological diagnosis through history, ORL inspection, ENG, calorics, rotatory chair test,
cranio-corpo-graphy (CCG), optokinetics, psychophysical audiometry, acoustic brainstem
and late evoked potentials, visually evoked potentials etc.. On this knowledge base we are
designing an individually adapted case oriented drug therapy.
Nausea and vomitus are the important subjective complications of dysequilibrium states.
Therefore antivertiginous and antiemetic therapies have to be applied if necessary. Usually
the duration is of limited time.
Oher drugs being chosen for a supportive pharmaco therapy according to the functional
topodiagnostics of the lesions usually possess one or more of the following actions upon the
equilibrium regulating network:
1. increase of cerebral blood flow,
2. enhanced penetration through the blood brain barrier,
3. increase of neuronal metabolism and
4. stabilization of specific neurotransmitters.
The neurootological patients are treated and monitored by regular neurootometric follow up
investigations.