TREATMENT OF VESTIBULAR VERTIGO: COMPARISON OF A FIXED COMBINATION OF CINNARIZINE 20MG AND DIMENHYDRINATE 40MG WITH THE 2.5-FOLD HIGHER DOSED ACTIVE DRUGS IN MONOTHERAPY

Authors

PhD Irene Bognar-Steinberg (, Germany)
PhD Wolfgang Baumann (, Germany)
Dr. med. Wieslau Skurczynski (, Germany)
Dr. med Lutz Kessler (, Germany)

Proceedings

ASN-Volume 7 - 2012

Topics

Neurootology
Neurootologic therapy
Neurootology
Neurootology
Neurootologic therapy
Pharmacotherapy

Keywords

central vertigo, Cinnarizine, Dimenhydrinate, peripheral vertigo, Vestibular system.

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Abstract

ABSTRACT
Objective: Efficacy and tolerability of the fixed combination cinnarizine 20mg/dimenhydrinate 40mg was compared to cinnarizine 50mg and dimenhydrinate 100mg in peripheral, central or mixed peripheral/central vertigo.
Methods: 189 patients were randomized to receive 1 tablet of medication, 3 times daily, for 4 weeks. Vertigo (‘mean vertigo score’, MVS) and concomitant symptoms, balance (craniocorpography) and nystagmus testing (electronystagmography) were assessed at baseline, and after one (t1w) and four weeks (t4w) of therapy.
Results: The fixed combination led to better improvements in MVS (primary outcome) than cinnarizine (p The majority of the patients rated the tolerability of the medications as ‘good’ or ‘very good’.
Conclusions: The results demonstrate that the fixed low-dose combination of cinnarizine 20mg and dimenhydrinate 40mg is an effective and well tolerated therapeutic option for vertigo of various origins. When given in fixed combination, the two active substances act synergistically, showing a higher efficacy than the monotherapies at the usual 2.5-fold higher doses.