Dimenhydrinate

ABSTRACT Objective: Efficacy and tolerability of the fixed combination cinnarizine 20mg/dimenhydrinate 40mg was compared to cinnarizine 50mg and dimenhydrinate 100mg in peripheral, central or mixed peripheral/central vertigo. Methods: 189 patients were randomized to receive 1 tablet of medication, 3 times daily, for 4 weeks. Vertigo (‘mean vertigo score’, MVS) and concomitant symptoms, balance (craniocorpography) and […]

ABSTRACT Background: Ménière’s disease (MD) is characterized by recurrent, sudden episodes of disabling vertigo. A previous randomized, controlled study demonstrated a high efficacy of a fixed combination of cinnarizine 20mg and dimenhydrinate 40mg (Arlevert®, tid.) in MD, with no statistically significant difference to betahistine (dimesylate salt, 12mg, tid). Objective: This post hoc analysis was performed […]

In a randomized, double-blind clinical study, we evaluated the efficacy and tolerability of the fixed combination of cinnarizine, 20 mg, and dimenhydrinate, 40 mg (Arlevert [ARL]) in comparison to betahistine dimesylate (12 mg) in 82 patients suffering from Ménière’s disease for at least 3 months and showing the characteristic triad of symptoms (paroxysmal vertigo attacks, […]