The role of free radicals and plasmatic antioxidant in menière syndrome
- Authors
- Prof. Dr. Antonio Cesarani (Milan, Italy)
Dr. med. Dario Alpini (Milan, Italy)
Dr. med. G. Raponi (Milan, Italy)
Dr. med. S. Volonte (Milan, Italy) - Proceedings
- XXVIII Congress of the NES - Alghero - Italy
- Topics
- Neurootology
Equilibrium
Diseases
Neurootology
Equilibrium
Neurootology
Neurootologic therapy
Neurootology
Neurootology
Neurootologic therapy
Pharmacotherapy - Keywords
- Antioxidant therapy, Ménière's disease, Microtoxicosis.
- Download
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Abstract
The objective of this study is the supposition, verified through suitable hematochemical tests, of the co-presence in the etiopathogenesis of the Menière syndrome and/or in the labyrinth pathologies or hypacusia also of central/systemic microtoxicosis. We do not therefore exclude other well known hypotheses on the causality of these pathologies, but one finds, above all in the Menière cases, a constant homogeneous distribution of the metabolic products of this microtoxicosis, such as the presence of a high concentration of free radicals and low natural defences like the antioxidant plasmatic capacity. A kind therefore of dangerous central and systemic presence of reactive molecules towards the pufa and towards the homeostatic complex enzymes, not compensated for by the natural antioxidant defence.The certain presence of this lack of balance , verified by suitable tests, has shown the rationality of use of a product made from reduced glutathione, thioctic acid, cysteine and other antioxidants, as a multipurpose antidote towards this hypothesis of etiopathogenesis. Patients divided in three groups (control, conventional therapy and antioxidant treatment), have shown a net and more significant improvement in the gluta/tios group and above all in the Menière syndrome group. Also the parallel clinical and instrumental evaluations sustain this new therapeutic solution which, already positively demonstrated, will be the object of further evidence to support this primary hypothesis.
