ISSN 1612-3352

Editors in Chief

Prof. Dr. Claus F. Claussen, Neurootological Research Institute of the Research Society for Smell, Taste, Hearing and Equilibrium Disorders at Bad Kissingen (4-G-F). Bad Kissingen, Germany.
Dr. med. Julia M. Bergmann,
Dr. med. Guillermo O. Bertora,
Otoneuroophthalmological Neurophysiology,
Buenos Aires, Argentina.

Production Managers

Dr. med. Julia M. Bergmann,
Dr. med. Guillermo O. Bertora,
Otoneuroophthalmological Neurophysiology,
Buenos Aires, Argentina.


Associated Editors


The editors welcome authors to submit articles for publications in the ASN.

Read the Information for Authors.


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Contribution of high click stimulus repetition rate in auditory evoked potentials in multiple sclerosis patients with normal mri

Abstract

The purpose of this work was to evaluate if a stimulus reptition rate that is higher than 30 clicks/sec increases the sensitivity of the absolute latencies of waves I, III and V and interpeak intervals I-III, III-V and I-V in the Auditory Brainstem Responses.(ABR) of Multiple Sclerosis (MS) patients.
Method: The ABR results of 20 female and 9 male MS patients (according to Poser’s Classification, but normal brainstem magnetic resonance imaging ) were compared to the results of 20 female and 20 male controls. 2000clicks of 100ms and at 60dBSPL above psychoacoustic threshold for clicks were delivered monoaurally with a TDH-39 supra-aural transducer, and white noise counter-lateral masking, at 11clicks/sec. Rarified polarity, 100Hz and 2500Hz filters and a 12ms window were used. All subjects were submitted do a progressively higher repetition of the stimulus, i.e. 31,51, 61 clicks/sec in subsequent ABR exams of the right ear followed by the left ear. Results: There was a statistically significant difference in the absolute latency of wave III in the MS group using 51 and 61 clicks/sec, wave V using 51 and 61 clicks/sec in the male MS group and I-III interval using 51 and 61clicks/sec in the male MS group. Conclusion: ABR using a stimulus rate of 51 and 61 clicks/sec should be included in the diagnosis of patients with a hypothisis of a demyeliating disease such as MS.

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