ISSN 1612-3352

Editors in Chief

Prof. Dr. Claus F. Claussen, Neurootological Research Institute of the Research Society for Smell, Taste, Hearing and Equilibrium Disorders at Bad Kissingen (4-G-F). Bad Kissingen, Germany.
Dr. med. Julia M. Bergmann,
Dr. med. Guillermo O. Bertora,
Otoneuroophthalmological Neurophysiology,
Buenos Aires, Argentina.

Production Managers

Dr. med. Julia M. Bergmann,
Dr. med. Guillermo O. Bertora,
Otoneuroophthalmological Neurophysiology,
Buenos Aires, Argentina.


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The editors welcome authors to submit articles for publications in the ASN.

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Assessment of serum antibodies to inner ear in patients with meniÈre’s disease

Abstract

Meniere’s disease (MD) is an idiopathic inner ear disorder characterized by fluctuating hearing loss, episodic vertigo and tinnitus of unknown etiology. There are growing evidences that autoimmunity may be involved in its development. We studied the reactivity to bovine inner ear antigens by Western blot immunoassay in sera from patients affected by MD, previously extensively studied for the presence of antibodies to collagens and membrane proteins. Reactivity to inner ear antigens of molecular weight of 44 and 53 kD was present respectively in 11/25 (44%) and 10/25 (40%) of patients, both antigens were absent in sera of healthy donors. It is still unclear whether the antibodies to 44 and 53 kD proteins are important in the pathogenesis of MD or rather represent the result of inflammation and tissue destruction. Even in this case, they could contribute to the perpetuation of the disease or play a role as a cofactor in association with other mechanisms.

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