A study to evaluate the efficacy and safety of a single infusion of caroverine in cases of

Authors

Dr. med. Sandra Desa Souza (, )
Dr. med. D. D’Souza (Mumbai, India)
Dr. med. J. Kochure (Mumbai, India)
Dr. med. V. Khandhar (Mumbai, India)
Dr. med. V. Ahuja (, )

Proceedings

XXX Congress of the NES - Oporto - Portugal

Topics

Sensology
Hearing
Diseases
Sensology
Hearing
Sensology
Sensology
Hearing
Therapy

Keywords

Caroverine, Cochlear tinnitus, Therapy, Tinnitus.

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Abstract

Caroverine a quinoxaline derivative, with glutamate antagonistic activity was used for cochlear synaptic tinnitus. A pilot study was done first in 4 cases at our centre. Two cases with pure cochlear synaptic tinnitus responded well to Caroverine while other two cases had tinnitus due to middle ear pathology and did not respond. Encouraged by these results, a double blind randomized study with exclusion criteria was carried out in 60 patients between the age group of 18 and 60 years with cochlear synaptic tinnitus. It showed improvement in 60% patients who received Caroverine and in 34.5% patients who received a placebo, showing that Caroverine (P<0.05) is significantly effective in the control of Tinnitus.