ISSN 1612-3352

Editors in Chief

Prof. Dr. Claus F. Claussen, Neurootological Research Institute of the Research Society for Smell, Taste, Hearing and Equilibrium Disorders at Bad Kissingen (4-G-F). Bad Kissingen, Germany.
Dr. med. Julia M. Bergmann,
Dr. med. Guillermo O. Bertora,
Otoneuroophthalmological Neurophysiology,
Buenos Aires, Argentina.

Production Managers

Dr. med. Julia M. Bergmann,
Dr. med. Guillermo O. Bertora,
Otoneuroophthalmological Neurophysiology,
Buenos Aires, Argentina.


Associated Editors


The editors welcome authors to submit articles for publications in the ASN.

Read the Information for Authors.


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A study to evaluate the efficacy and safety of a single infusion of caroverine in cases of

Abstract

Caroverine a quinoxaline derivative, with glutamate antagonistic activity was used for cochlear synaptic tinnitus. A pilot study was done first in 4 cases at our centre. Two cases with pure cochlear synaptic tinnitus responded well to Caroverine while other two cases had tinnitus due to middle ear pathology and did not respond. Encouraged by these results, a double blind randomized study with exclusion criteria was carried out in 60 patients between the age group of 18 and 60 years with cochlear synaptic tinnitus. It showed improvement in 60% patients who received Caroverine and in 34.5% patients who received a placebo, showing that Caroverine (P<0.05) is significantly effective in the control of Tinnitus.

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