Therapy

Caroverine a quinoxaline derivative, with glutamate antagonistic activity was used for cochlear synaptic tinnitus. A pilot study was done first in 4 cases at our centre. Two cases with pure cochlear synaptic tinnitus responded well to Caroverine while other two cases had tinnitus due to middle ear pathology and did not respond. Encouraged by these […]

Microthrombotic vascular lesions could be the primary or secondary cause but, however, in most of the cases are at the base of the lesions of tinnitus. On those bases we consider that a therapy with enoxaparine has a wide field of action. Two hundred cases of patients, who had suffered from tinnitus for at least […]

The chemical element zinc has been in the last decades strongly studied. It is well known that it is present in some different structures of the Central Nervous System, acting as a co-factor of excitatory glutamatergic synapsis. Its function is not yet fully understood, but it seems to modulate the sensibility of glutamatergic post-sinaptic receptors […]

Some authors have postulate that sistemic zinc can be employed in the threatment of tinnitus, because a sub-clinical hypozincemia is suposed to promote this auditory disturbance. However, in the majority of the cases of tinnitus, this hypozincemia was not confirmed. There is not enough randomized studies that could show the relationship between zinc and tinnitus. […]

It has long been suspected that an important relationship exists between inner and outer hair cells, and that a disturbance of this relationship could lead to the phenomenon of tinnitus. The electromodel of the auditory system describes one mechanism of this inter-hair cell relationship. Following this model a mechanism exists, driven by mechanosensitive outer hair […]

The etiology of tinnitus combines hereditary and environmental factors. To help develop optimal therapies for tinnitus, it is necessary to characterize the genetic contributors to the pathophysiology and to design treatments at the level of the gene. Inner ear gene therapy involves delivery of genes into the vestibular or auditory portions of the inner ear […]

On the ENT Dept at 3rd Medical Faculty of Charles University Prague has been used 15 IEC for the therapy at chronic tinnitus. The succes ratio is evaluated by the mean of visual analogue scala (VAS) and by tinnitometr i.e. by meassurment of intensity (dB) and frequency (Hz) of tinnitus. Duration of tinnitus oscillated between […]

Although tinnitus is defined as an internal auditory sensation, external auditory stimuli can mask tinnitus under some circumstances. High-frequency vibration delivered as bone conduction stimulation is effective in masking high-pitched tinnitus. In this preliminary report, somatosensory stimulation in the form of low-frequency muscle vibration can also mask high-frequency tinnitus. Somatosensory stimulation provides fast, immediate relief, […]

Objective/Hypothesis: The purpose of this study is to assess the efficacy of hydroxyethyl starch (HES 200) in the treatment of sudden deafness of vascular origin, and compare it with that of dextran 40. Study Design: Prospective study Methods: Ten patients with sudden deafness of vascular origin undergoing HES 200 therapy with the treatment program as […]

In this report, we summarize our clinical experience with intratympanic dexamethasone treatment (IDT) for control of tinnitus.